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Maria Zi­m­mer­mann-Kogadeeva and Mi­chael Zi­m­mer­mann: Quan­ti­fy­ing mi­cro­bi­ota-host meta­bolic in­ter­ac­tions

Sep 8, 2022
Join our in­vit­a­tional sem­inar!

Thursday, Septem­ber 8, 2022
at 3:00 p.m. (15:00 Uhr) in the lec­ture hall 4012


Maria Zimmermann-Kogadeeva and Michael Zimmermann (EMBL, Heidel­berg, Ger­many)

will give a sem­inar with the title:

"Quantifying microbiota-host metabolic interactions"

 You are wel­come to join.

 
Lecture hall
Lecture hall

Quantifying microbiota-host metabolic interaction

The gut mi­cro­bi­ota plays an es­sen­tial role in host health, help­ing to cata­bol­ize in­di­gest­ible nu­tri­ents and en­ga­ging in host meta­bol­ism. However, quan­ti­fy­ing mi­cro­bi­ota-host meta­bolic in­ter­ac­tions is chal­len­ging due to the com­plex­ity of host-mi­cro­bi­ota re­la­tion­ships and the fact that most meta­bol­ites are in­dis­tin­guish­able between or­gan­isms. To dis­en­tangle mi­cro­bi­ota and host con­tri­bu­tions to the meta­bol­ism of med­ical drugs and di­et­ary com­pounds, we com­bine con­trolled gno­to­bi­otic mouse ex­per­i­ments and mul­tiom­ics data in­teg­ra­tion with math­em­at­ical mod­el­ling and meta­bolic net­work ana­lysis. To identify bac­terial play­ers and their path­ways re­spons­ible for the mi­cro­bi­ota-as­so­ci­ated meta­bol­ism, we com­bine high-through­put bac­terial ge­net­ics and meta­bolo­m­ics screens in vitro. This com­bin­a­tion of ex­per­i­mental and com­pu­ta­tional ap­proaches un­ravels mech­an­istic links between drugs, diet, mi­cro­bi­ota and the host, and provides in­sights into how com­pos­i­tional shifts and meta­bolic ad­apt­a­tion of single bac­teria might af­fect com­munity meta­bol­ism.

To join the sem­inar on­line, please use the fol­low­ing link:

 

For fur­ther in­form­a­tion, please get in touch!

 
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