- Departments
- Department of Biogeochemistry
- Microbial Physiology Research Group
- People
- Paloma Garrido Amador
Paloma Garrido Amador
Microbial Physiology Research Group
MPI for Marine Microbiology
Celsiusstr. 1
D-28359 Bremen
Germany
Room: |
3137 |
Phone: |
Nitric oxide (NO) is a free radical gas with important functions in cell biology and atmospheric chemistry. Due to its high reactivity and its interactions with other radicals, NO is a very potent toxin that can inhibit microbial growth. For this reason, many bacteria detoxify NO employing an array of proteins to either reduce it or oxidize it to less reactive compounds. In some groups of bacteria, NO is utilized as a signaling molecule, regulating processes such as biofilm formation and dispersal, motility and quorum sensing. NO is also a key intermediate of various microbial nitrogen turnover processes, including denitrification, aerobic ammonia and anaerobic ammonium oxidation, and even nitrite-dependent anaerobic methane oxidation by methanotrophic bacteria. Since NO is present in cells at very low concentrations, transformed very rapidly, and toxic, its direct use for microbial respiration has been largely overlooked.
My research focuses on microorganisms that can obtain energy from NO transformations. Using continuous and fed-batch bioreactors and samples from natural and engineered environments, my objective is to discover and describe energy-conserving biochemical reactions involving NO, as well as the microorganisms and the enzymes involved.